Application
RB1CC1 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the RB1CC1 antibody detected the RB1CC1 protein (arrow).| Product Name | RB1CC1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0203, RBICC |
|---|---|
| Alternative Names | RB1CC1 KIAA0203 RBICC RB1-inducible coiled-coil protein 1 FAK family kinase-interacting protein of 200 kDa |
| Molecular Weight(MW) | 183091 Da |
| Function | Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Involved in autophagy Required for autophagosome formation (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways |
| Tissue Specificity | Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells |
| Cellular Localization | Nucleus. Cytoplasm, cytosol. Preautophagosomal structure (By similarity). Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity) |
| Entrez Gene | 9821 |
|---|---|
| Nucleotide Accession | NP_001077086.1 NP_055596.3 |
Application
RB1CC1 Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the RB1CC1 antibody detected the RB1CC1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
