Application
RBM5 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RBM5 antibody detected the RBM5 protein (arrow).| Product Name | RBM5 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RBM5; RNA-binding protein 5; Protein G15; Putative tumor suppressor LUCA15; RNA-binding motif protein 5; Renal carcinoma antigen NY-REN-9 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | RBM5 RNA-binding protein 5 Protein G15 Putative tumor suppressor LUCA15 RNA-binding motif protein 5 Renal carcinoma antigen NY-REN-9 |
|---|---|
| Molecular Weight(MW) | 92154 Da |
| Function | Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis |
| Tissue Specificity | Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines |
| Cellular Localization | Nucleus. |
| Entrez Gene | 10181 |
|---|---|
| Nucleotide Accession | NP_005769.1 |
Application
RBM5 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RBM5 antibody detected the RBM5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
