Application
REC8 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the REC8 antibody detected the REC8 protein (arrow).| Product Name | REC8 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | REC8; REC8L1; Meiotic recombination protein REC8 homolog; Cohesin Rec8p |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | REC8L1 |
|---|---|
| Alternative Names | REC8 REC8L1 Meiotic recombination protein REC8 homolog Cohesin Rec8p |
| Molecular Weight(MW) | 62614 Da |
| Function | Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity) |
| Tissue Specificity | Expressed in testis and thymus. |
| Cellular Localization | Nucleus (By similarity). Chromosome (By similarity). Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity) |
| Entrez Gene | 9985 |
|---|---|
| Nucleotide Accession | NP_005123.2 NP_001041670.1 |
Application
REC8 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the REC8 antibody detected the REC8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
