Application
RFX3 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the RFX3 antibody detected the RFX3 protein (arrow).| Product Name | RFX3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RFX3; Transcription factor RFX3; Regulatory factor X 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | RFX3 Transcription factor RFX3 Regulatory factor X 3 |
|---|---|
| Molecular Weight(MW) | 83530 Da |
| Function | Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity) Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells |
| Tissue Specificity | This RFX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 660-690 amino acids from the C-terminal region of human RFX3. |
| Cellular Localization | Nucleus (Probable). |
| Entrez Gene | 5991 |
|---|---|
| Nucleotide Accession | NP_002910.1 NP_602304.1 |
Application
RFX3 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the RFX3 antibody detected the RFX3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
