Application
RIC8A Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RIC8A antibody detected the RIC8A protein (arrow).| Product Name | RIC8A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | RIC8A Synembryn-A Protein Ric-8A |
|---|---|
| Molecular Weight(MW) | 59710 Da |
| Function | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation |
| Tissue Specificity | This RIC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human RIC8A. |
| Cellular Localization | Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity) |
| Entrez Gene | 60626 |
|---|---|
| Nucleotide Accession | NP_068751.4 |
Application
RIC8A Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RIC8A antibody detected the RIC8A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
