Application
RNF41 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).| Product Name | RNF41 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FLRF, NRDP1 |
|---|---|
| Alternative Names | RNF41 FLRF NRDP1 E3 ubiquitin-protein ligase NRDP1 RING finger protein 41 |
| Molecular Weight(MW) | 35905 Da |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state |
| Tissue Specificity | Detected in ovary, testis and prostate. |
| Entrez Gene | 10193 |
|---|---|
| Nucleotide Accession | NP_005776.1 |
Application
RNF41 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RNF41 antibody detected the RNF41 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
