Application
RRM2B Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RRM2B antibody detected the RRM2B protein (arrow).| Product Name | RRM2B Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RRM2B; P53R2; Ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | P53R2 |
|---|---|
| Alternative Names | RRM2B P53R2 Ribonucleoside-diphosphate reductase subunit M2 B TP53-inducible ribonucleotide reductase M2 B p53-inducible ribonucleotide reductase small subunit 2-like protein |
| Molecular Weight(MW) | 40737 Da |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2 Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage |
| Tissue Specificity | Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma |
| Cellular Localization | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage |
| Entrez Gene | 50484 |
|---|---|
| Nucleotide Accession | NP_001165948.1 NP_001165949.1 |
Application
RRM2B Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RRM2B antibody detected the RRM2B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
