Application
SATB2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SATB2 antibody detected the SATB2 protein (arrow).| Product Name | SATB2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SATB2; KIAA1034; DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1034 |
|---|---|
| Alternative Names | SATB2 KIAA1034 DNA-binding protein SATB2 Special AT-rich sequence-binding protein 2 |
| Molecular Weight(MW) | 82555 Da |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation |
| Tissue Specificity | High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus |
| Cellular Localization | Nucleus matrix. |
| Entrez Gene | 23314 |
|---|---|
| Nucleotide Accession | NP_056080.1 |
Application
SATB2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SATB2 antibody detected the SATB2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
