Application
SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).| Product Name | SCN5A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SCN5A; Sodium channel protein type 5 subunit alpha; HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SCN5A Sodium channel protein type 5 subunit alpha HH1 Sodium channel protein cardiac muscle subunit alpha Sodium channel protein type V subunit alpha Voltage-gated sodium channel subunit alpha Nav1.5 |
|---|---|
| Molecular Weight(MW) | 226940 Da |
| Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels |
| Tissue Specificity | Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 6331 |
|---|---|
| Nucleotide Accession | NP_000326.2 |
Application
SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
