SPTLC2; KIAA0526; LCB2; Serine palmitoyltransferase 2; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine-palmitoyl-CoA transferase 2
Key Feature
Clonality
Polyclonal
Isotype
Ig
Host Species
Rabbit
Tested Applications
WB
WB:1:100~500
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
KIAA0526 LCB2
Alternative Names
SPTLC2 KIAA0526 LCB2 Serine palmitoyltransferase 2 Long chain base biosynthesis protein 2 Long chain base biosynthesis protein 2a Serine-palmitoyl-CoA transferase 2
Molecular Weight(MW)
62924 Da
Function
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate
Tissue Specificity
Widely expressed.
Cellular Localization
Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
The anti-SPTLC2 Pab is used in Western blot to detect SPTLC2 in mouse liver tissue lysate.
Application Notes
WB:1:100~500
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.