Application
SFRP4 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SFRP4 antibody detected the SFRP4 protein (arrow).Application
SFRP4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SFRP4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | SFRP4 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SFRP4; FRPHE; Secreted frizzled-related protein 4; Frizzled protein, human endometrium |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FRPHE |
|---|---|
| Alternative Names | SFRP4 FRPHE Secreted frizzled-related protein 4 Frizzled protein human endometrium |
| Molecular Weight(MW) | 39827 Da |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake |
| Tissue Specificity | Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level) |
| Cellular Localization | Secreted. Note=Cytoplasmic in ovarian tumor cells |
| Entrez Gene | 6424 |
|---|---|
| Nucleotide Accession | NP_003005.2 |
Application
SFRP4 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SFRP4 antibody detected the SFRP4 protein (arrow).
Application
SFRP4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SFRP4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
