Application
A. Western blot analysis on Jurkat cell lysate using anti-SHP-2 RabMAb (Cat. #AJ1716a) 1:5,000 dilutionApplication
B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-SHP-2 RabMAb (Cat. #AJ1716a).| Product Name | SHP-2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | Y478 |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PTP2C, SHPTP2 |
|---|---|
| Alternative Names | PTPN11 PTP2C SHPTP2 Tyrosine-protein phosphatase non-receptor type 11 PTP-1D SH-PTP3 SH-PTP2 |
| Molecular Weight(MW) | 68436 Da |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 5781 |
|---|
Application
A. Western blot analysis on Jurkat cell lysate using anti-SHP-2 RabMAb (Cat. #AJ1716a) 1:5,000 dilution
Application
B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-SHP-2 RabMAb (Cat. #AJ1716a).| Application Notes | WB:1:500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
