Application
PTPN11 Antibody (Cat. #AM1920b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).Application
PTPN11 Antibody (Cat. #AM1920b) western blot analysis in mouse brian tissue lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).| Product Name | PTPN11 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 246CT9.8.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PTP2C, SHPTP2 |
|---|---|
| Alternative Names | PTPN11 PTP2C SHPTP2 Tyrosine-protein phosphatase non-receptor type 11 Protein-tyrosine phosphatase 1D Protein-tyrosine phosphatase 2C SH-PTP2 SH-PTP3 |
| Molecular Weight(MW) | 68436 Da |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 5781 |
|---|---|
| Nucleotide Accession | NP_002825.3 |
Application
PTPN11 Antibody (Cat. #AM1920b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).
Application
PTPN11 Antibody (Cat. #AM1920b) western blot analysis in mouse brian tissue lysates (35ug/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).| Application Notes | WB:1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
