Application
SIGLEC10 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC10 antibody detected the SIGLEC10 protein (arrow).| Product Name | SIGLEC10 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SIGLEC10; SLG2; Sialic acid-binding Ig-like lectin 10; Siglec-like protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SLG2 |
|---|---|
| Alternative Names | SIGLEC10 SLG2 Sialic acid-binding Ig-like lectin 10 Siglec-like protein 2 |
| Molecular Weight(MW) | 76592 Da |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules |
| Tissue Specificity | Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation) Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Secreted. |
| Entrez Gene | 89790 |
|---|---|
| Nucleotide Accession | NP_001164628.1 NP_001164627.1 |
Application
SIGLEC10 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC10 antibody detected the SIGLEC10 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
