Application
SIGLEC11 Antibody western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC11 antibody detected the SIGLEC11 protein (arrow).Application
SIGLEC11 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SIGLEC11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | SIGLEC11 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SIGLEC11; Sialic acid-binding Ig-like lectin 11 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SIGLEC11 Sialic acid-binding Ig-like lectin 11 |
|---|---|
| Molecular Weight(MW) | 75795 Da |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules |
| Tissue Specificity | Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 114132 |
|---|
Application
SIGLEC11 Antibody western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC11 antibody detected the SIGLEC11 protein (arrow).
Application
SIGLEC11 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SIGLEC11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
