Application
Western blot analysis of SLC11A1 Antibody (Center) in CEM cell line lysates (35ug/lane). SLC11A1 (arrow) was detected using the purified Pab.Application
Confocal immunofluorescent analysis of SLC11A1 Antibody (Center)(Cat#AP8514c) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).| Product Name | SLC11A1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:100~500 IF |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LSH, NRAMP, NRAMP1 |
|---|---|
| Alternative Names | SLC11A1 LSH NRAMP NRAMP1 Natural resistance-associated macrophage protein 1 |
| Molecular Weight(MW) | 59872 Da |
| Function | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes |
| Tissue Specificity | Macrophages; peripheral blood leukocytes, lung, spleen and liver |
| Cellular Localization | Membrane; Multi-pass membrane protein (Probable) |
| Entrez Gene | 6556 |
|---|
Application
Western blot analysis of SLC11A1 Antibody (Center) in CEM cell line lysates (35ug/lane). SLC11A1 (arrow) was detected using the purified Pab.
Application
Confocal immunofluorescent analysis of SLC11A1 Antibody (Center)(Cat#AP8514c) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).| Application Notes | WB:1:100~500 IF |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
