Application
SLC12A4 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SLC12A4 antibody detected the SLC12A4 protein (arrow).| Product Name | SLC12A4 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KCC1 |
|---|---|
| Alternative Names | SLC12A4 KCC1 Solute carrier family 12 member 4 Electroneutral potassium-chloride cotransporter 1 Erythroid K-Cl cotransporter 1 |
| Molecular Weight(MW) | 120650 Da |
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity |
| Tissue Specificity | Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 6560 |
|---|---|
| Nucleotide Accession | NP_005063.1 |
Application
SLC12A4 Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SLC12A4 antibody detected the SLC12A4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
