Application
SLC47A1 Antibody (C-term) western blot analysis in HepG2(lane 1),MDA-MB435(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC47A1 antibody detected the SLC47A1 protein (arrow).Application
SLC47A1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC47A1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | SLC47A1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLC47A1; MATE1; Multidrug and toxin extrusion protein 1; Solute carrier family 47 member 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MATE1 |
|---|---|
| Alternative Names | SLC47A1 MATE1 Multidrug and toxin extrusion protein 1 Solute carrier family 47 member 1 |
| Molecular Weight(MW) | 61922 Da |
| Function | Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent) Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes |
| Tissue Specificity | Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles |
| Entrez Gene | 55244 |
|---|---|
| Nucleotide Accession | NP_060712.2 |
Application
SLC47A1 Antibody (C-term) western blot analysis in HepG2(lane 1),MDA-MB435(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC47A1 antibody detected the SLC47A1 protein (arrow).
Application
SLC47A1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC47A1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
