Application
SLC46A1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SLC46A1 antibody detected the SLC46A1 protein (arrow).| Product Name | SLC46A1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLC46A1; HCP1; PCFT; Proton-coupled folate transporter; G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HCP1 PCFT |
|---|---|
| Alternative Names | SLC46A1 HCP1 PCFT Proton-coupled folate transporter G21 Heme carrier protein 1 PCFT/HCP1 Solute carrier family 46 member 1 |
| Molecular Weight(MW) | 49771 Da |
| Function | Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme |
| Tissue Specificity | Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein. Cytoplasm (By similarity). Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity) |
| Entrez Gene | 113235 |
|---|---|
| Nucleotide Accession | NP_542400.2 |
Application
SLC46A1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SLC46A1 antibody detected the SLC46A1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
