Application
SLC4A8 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SLC4A8 antibody detected the SLC4A8 protein (arrow).| Product Name | SLC4A8 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLC4A8; KIAA0739; NBC; NBC3; NDCBE1; Electroneutral sodium bicarbonate exchanger 1; Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0739 NBC NBC3 NDCBE1 |
|---|---|
| Alternative Names | SLC4A8 KIAA0739 NBC NBC3 NDCBE1 Electroneutral sodium bicarbonate exchanger 1 Electroneutral Na(+)-driven Cl-HCO3 exchanger Solute carrier family 4 member 8 k-NBC3 |
| Molecular Weight(MW) | 122938 Da |
| Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity |
| Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| Entrez Gene | 9498 |
|---|---|
| Nucleotide Accession | NP_001035049.1 |
Application
SLC4A8 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SLC4A8 antibody detected the SLC4A8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
