Application
SLCO4C1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SLCO4C1 antibody detected the SLCO4C1 protein (arrow).Application
SLCO4C1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLCO4C1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
SLCO4C1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | SLCO4C1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLCO4C1; OATP4C1; OATPX; SLC21A20; Solute carrier organic anion transporter family member 4C1; OATP-H; Organic anion transporter M1; Solute carrier family 21 member 20 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | OATP4C1 OATPX SLC21A20 |
|---|---|
| Alternative Names | SLCO4C1 OATP4C1 OATPX SLC21A20 Solute carrier organic anion transporter family member 4C1 OATP-H Organic anion transporter M1 Solute carrier family 21 member 20 |
| Molecular Weight(MW) | 78948 Da |
| Function | Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion- transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg |
| Tissue Specificity | Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein (By similarity). Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney (By similarity) |
| Entrez Gene | 353189 |
|---|---|
| Nucleotide Accession | NP_851322.3 |
Application
SLCO4C1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SLCO4C1 antibody detected the SLCO4C1 protein (arrow).
Application
SLCO4C1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLCO4C1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
SLCO4C1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
