Application
SMAD6 Antibody (C-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SMAD6 antibody detected the SMAD6 protein (arrow).| Product Name | SMAD6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SMAD6; MADH6; Mothers against decapentaplegic homolog 6; SMAD family member 6 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MADH6 |
|---|---|
| Alternative Names | SMAD6 MADH6 Mothers against decapentaplegic homolog 6 SMAD family member 6 |
| Molecular Weight(MW) | 53497 Da |
| Function | Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions |
| Tissue Specificity | Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue |
| Cellular Localization | Nucleus. |
| Entrez Gene | 4091 |
|---|---|
| Nucleotide Accession | NP_005576.3 |
Application
SMAD6 Antibody (C-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the SMAD6 antibody detected the SMAD6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
