Application
SMARCB1 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow).Application
SMARCB1 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow).| Product Name | SMARCB1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SMARCB1; BAF47; INI1; SNF5L1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; BRG1-associated factor 47; Integrase interactor 1 protein; SNF5 homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BAF47 INI1 SNF5L1 |
|---|---|
| Alternative Names | SMARCB1 BAF47 INI1 SNF5L1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 BRG1-associated factor 47 Integrase interactor 1 protein SNF5 homolog |
| Molecular Weight(MW) | 44141 Da |
| Function | Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene |
| Tissue Specificity | This SMARCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the N-terminal region of human SMARCB1. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 6598 |
|---|---|
| Nucleotide Accession | NP_001007469.1 NP_003064.2 |
Application
SMARCB1 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow).
Application
SMARCB1 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
