Application
SNX17 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SNX17 antibody detected the SNX17 protein (arrow).| Product Name | SNX17 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SNX17; KIAA0064; Sorting nexin-17 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0064 |
|---|---|
| Alternative Names | SNX17 KIAA0064 Sorting nexin-17 |
| Molecular Weight(MW) | 52901 Da |
| Function | Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) |
| Tissue Specificity | This SNX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human SNX17. |
| Cellular Localization | Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side |
| Entrez Gene | 9784 |
|---|---|
| Nucleotide Accession | NP_055563.1 |
Application
SNX17 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SNX17 antibody detected the SNX17 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
