Application
SOCS3 Antibody (Cat. #AM2154a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SOCS3 antibody detected the SOCS3 protein (arrow).| Product Name | SOCS3 Antibody (Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SOCS3; CIS3; SSI3; Suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; STAT-induced STAT inhibitor 3 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 532CT13.5.3 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:500~1600" |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CIS3 SSI3 |
|---|---|
| Alternative Names | SOCS3 CIS3 SSI3 Suppressor of cytokine signaling 3 Cytokine-inducible SH2 protein 3 STAT-induced STAT inhibitor 3 |
| Molecular Weight(MW) | 24770 Da |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity) |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus |
| Entrez Gene | 9021 |
|---|---|
| Nucleotide Accession | NP_003946.3 |
Application
SOCS3 Antibody (Cat. #AM2154a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SOCS3 antibody detected the SOCS3 protein (arrow).| Application Notes | WB:1:500~1600" |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
