Application
A. Western blot analysis on fetal liver membrane using anti-SHH (c-product) RabMAb (Cat. #AJ1731a), dilution 1:2000.Application
B. Immunohistochemistry analysis of paraffin-embedded Human Kidney tissue using anti-SHH (C-Product) RabMAb (Cat. #AJ1731a).| Product Name | Sonic-Hedgehog (SHH) Antibody (C-Product) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SHH, Sonic hedgehog protein C-product, HHG-1 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1190Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000~10000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SHH Sonic hedgehog protein C-product HHG-1 |
|---|---|
| Molecular Weight(MW) | 49607 Da |
| Function | Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity) |
| Tissue Specificity | Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues |
| Cellular Localization | Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Note=The C-terminal peptide diffuses from the cell (By similarity) |
| Entrez Gene | 6469 |
|---|
Application
A. Western blot analysis on fetal liver membrane using anti-SHH (c-product) RabMAb (Cat. #AJ1731a), dilution 1:2000.
Application
B. Immunohistochemistry analysis of paraffin-embedded Human Kidney tissue using anti-SHH (C-Product) RabMAb (Cat. #AJ1731a).| Application Notes | WB:1:1000~10000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
