Application
SOX7 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SOX7 antibody detected the SOX7 protein (arrow).| Product Name | SOX7 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SOX7; Transcription factor SOX-7 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SOX7 Transcription factor SOX-7 |
|---|---|
| Molecular Weight(MW) | 42197 Da |
| Function | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3' |
| Tissue Specificity | Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation |
| Cellular Localization | Nucleus (By similarity). Cytoplasm. |
| Entrez Gene | 83595 |
|---|---|
| Nucleotide Accession | NP_113627.1 |
Application
SOX7 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SOX7 antibody detected the SOX7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
