Application
SPIRE1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPIRE1 antibody detected the SPIRE1 protein (arrow).| Product Name | SPIRE1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SPIRE1; KIAA1135; SPIR1; Protein spire homolog 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1135 SPIR1 |
|---|---|
| Alternative Names | SPIRE1 KIAA1135 SPIR1 Protein spire homolog 1 |
| Molecular Weight(MW) | 85544 Da |
| Function | Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis |
| Tissue Specificity | This SPIRE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 664-691 amino acids from the C-terminal region of human SPIRE1. |
| Cellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, co-localised with Rab11 |
| Entrez Gene | 56907 |
|---|---|
| Nucleotide Accession | NP_001122099.1 NP_001122098.1 |
Application
SPIRE1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPIRE1 antibody detected the SPIRE1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
