Application
SS18L1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SS18L1 antibody detected the SS18L1 protein (arrow).| Product Name | SS18L1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SS18L1; CREST; KIAA0693; Calcium-responsive transactivator; SS18-like protein 1; SYT homolog 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CREST KIAA0693 |
|---|---|
| Alternative Names | SS18L1 CREST KIAA0693 Calcium-responsive transactivator SS18-like protein 1 SYT homolog 1 |
| Molecular Weight(MW) | 42990 Da |
| Function | Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons Recruits CREB-binding protein (CREBBP) to nuclear bodies Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity) |
| Tissue Specificity | Ubiquitous; with lowest levels in spleen. |
| Cellular Localization | Nucleus (By similarity). Chromosome, centromere, kinetochore (By similarity). Note=Localizes to nuclear bodies. Co-localizes with SGOL1 at kinetochore (By similarity) |
| Entrez Gene | 26039 |
|---|---|
| Nucleotide Accession | NP_945173.1 |
Application
SS18L1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SS18L1 antibody detected the SS18L1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
