Application
The anti-STAM Pab is used in Western blot to detect STAM in mouse cerebellum tissue lysate.Application
Western blot analysis of STAM (arrow) using rabbit polyclonal STAM Antibody (D10) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the STAM gene.| Product Name | STAM Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STAM; STAM1; Signal transducing adapter molecule 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | STAM1 |
|---|---|
| Alternative Names | STAM STAM1 Signal transducing adapter molecule 1 |
| Molecular Weight(MW) | 59180 Da |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable) |
| Entrez Gene | 8027 |
|---|
Application
The anti-STAM Pab is used in Western blot to detect STAM in mouse cerebellum tissue lysate.
Application
Western blot analysis of STAM (arrow) using rabbit polyclonal STAM Antibody (D10) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the STAM gene.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
