Application
A. Western blot analysis on K562 cell lysate using anti-Stat-2 RabMAb (Cat. #AJ1738a), dilution 1:500.Application
B. Immunohistochemical analysis of paraffin-embedded human thyroid cancer using anti-Stat-2 RabMAb (Cat. #AJ1738a).| Product Name | Stat-2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STAT2, Signal transducer and activator of transcription 2, p113 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | Y141 |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | STAT2 Signal transducer and activator of transcription 2 p113 |
|---|---|
| Molecular Weight(MW) | 97916 Da |
| Function | Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state |
| Tissue Specificity | A synthetic peptide corresponding to residues near N-terminus of human Stat-2 was used as immunogen. This antibody detects both long and short forms of Stat-2. |
| Cellular Localization | Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta |
| Entrez Gene | 6773 |
|---|
Application
A. Western blot analysis on K562 cell lysate using anti-Stat-2 RabMAb (Cat. #AJ1738a), dilution 1:500.
Application
B. Immunohistochemical analysis of paraffin-embedded human thyroid cancer using anti-Stat-2 RabMAb (Cat. #AJ1738a).| Application Notes | WB:1:500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
