Application
STK36 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the STK36 antibody detected the STK36 protein (arrow).Application
STK36 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STK36 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | STK36 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STK36; KIAA1278; Serine/threonine-protein kinase 36; Fused homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1278 |
|---|---|
| Alternative Names | STK36 KIAA1278 Serine/threonine-protein kinase 36 Fused homolog |
| Molecular Weight(MW) | 143995 Da |
| Function | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia |
| Tissue Specificity | Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells |
| Cellular Localization | Cytoplasm. Nucleus. Note=Low levels also present in the nucleus |
| Entrez Gene | 27148 |
|---|---|
| Nucleotide Accession | NP_056505.2 |
Application
STK36 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the STK36 antibody detected the STK36 protein (arrow).
Application
STK36 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STK36 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
