Application
STOML2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the STOML2 antibody detected the STOML2 protein (arrow).| Product Name | STOML2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STOML2; SLP2; Stomatin-like protein 2; EPB72-like protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SLP2 |
|---|---|
| Alternative Names | STOML2 SLP2 Stomatin-like protein 2 EPB72-like protein 2 |
| Molecular Weight(MW) | 38534 Da |
| Function | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation |
| Tissue Specificity | Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level) |
| Cellular Localization | Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral membrane protein Membrane raft; Peripheral membrane protein. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells |
| Entrez Gene | 30968 |
|---|---|
| Nucleotide Accession | NP_038470.1 |
Application
STOML2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the STOML2 antibody detected the STOML2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
