Application
Western blot analysis of SUPV3L1 Antibody (N-term) in K562 cell line lysates (35ug/lane). SUPV3L1 (arrow) was detected using the purified Pab.Application
SUPV3L1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SUPV3L1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
SUPV3L1 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | SUPV3L1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SUPV3L1; SUV3; ATP-dependent RNA helicase SUPV3L1, mitochondrial; Suppressor of var1 3-like protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SUV3 |
|---|---|
| Alternative Names | SUPV3L1 SUV3 ATP-dependent RNA helicase SUPV3L1 mitochondrial Suppressor of var1 3-like protein 1 |
| Molecular Weight(MW) | 87991 Da |
| Function | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis Associates with mitochondrial DNA |
| Tissue Specificity | Broadly expressed. |
| Cellular Localization | Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid |
| Entrez Gene | 6832 |
|---|
Application
Western blot analysis of SUPV3L1 Antibody (N-term) in K562 cell line lysates (35ug/lane). SUPV3L1 (arrow) was detected using the purified Pab.
Application
SUPV3L1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SUPV3L1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
SUPV3L1 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
