Application
Western blot analysis of SUV4-20H2 antibody (Center) (Cat.# AP6511c) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.Application
SUV4-20H2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | SUV4-20H2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SUV420H2; KMT5C; Histone-lysine N-methyltransferase SUV420H2; Lysine N-methyltransferase 5C; Suppressor of variegation 4-20 homolog 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBFC |
| WB:1:50~100 FC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KMT5C |
|---|---|
| Alternative Names | SUV420H2 KMT5C Histone-lysine N-methyltransferase SUV420H2 Lysine N-methyltransferase 5C Suppressor of variegation 4-20 homolog 2 |
| Molecular Weight(MW) | 52113 Da |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity) |
| Tissue Specificity | This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194~223 amino acids from the Center region of human SUV420H2. |
| Cellular Localization | Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity) |
| Entrez Gene | 84787 |
|---|
Application
Western blot analysis of SUV4-20H2 antibody (Center) (Cat.# AP6511c) in mouse stomach tissue lysates (35ug/lane). SUV4-20H2 (arrow) was detected using the purified Pab.
Application
SUV4-20H2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:50~100 FC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
