Application
SWAP70 Antibody (Cat. #AM2029a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SWAP70 antibody detected the SWAP70 protein (arrow).| Product Name | SWAP70 Antibody(Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SWAP70; KIAA0640; Switch-associated protein 70 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 434CT16.5.5 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:1000~8000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0640 |
|---|---|
| Alternative Names | SWAP70 KIAA0640 Switch-associated protein 70 |
| Molecular Weight(MW) | 68998 Da |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity) |
| Tissue Specificity | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760) |
| Cellular Localization | Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia |
| Entrez Gene | 23075 |
|---|---|
| Nucleotide Accession | NP_055870.2 |
Application
SWAP70 Antibody (Cat. #AM2029a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SWAP70 antibody detected the SWAP70 protein (arrow).| Application Notes | WB:1:1000~8000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
