Application
SYNE3 Antibody (C-term) western blot analysis in mouse spleen cell line lysates (35ug/lane).This demonstrates the SYNE3 antibody detected the SYNE3 protein (arrow).Application
SYNE3 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hodgkin lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SYNE3 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | SYNE3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | C14orf49; Nesprin-3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C14orf49 |
|---|---|
| Alternative Names | C14orf49 Nesprin-3 |
| Molecular Weight(MW) | 112216 Da |
| Function | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells |
| Tissue Specificity | Expressed in aortic endothelial cells (at protein level) |
| Cellular Localization | Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Note=Localized uniformly throughout the nuclear envilope in aortic endothelial cells Located at the rough reticulum endoplasmic (RER) in some cells |
| Entrez Gene | 161176 |
|---|---|
| Nucleotide Accession | NP_689805.3 |
Application
SYNE3 Antibody (C-term) western blot analysis in mouse spleen cell line lysates (35ug/lane).This demonstrates the SYNE3 antibody detected the SYNE3 protein (arrow).
Application
SYNE3 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hodgkin lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SYNE3 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
