Application
Western blot analysis of anti-TAOK1 Pab (AP7085c) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab (1:60 dilution).| Product Name | TAOK1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TAOK1; KIAA1361; MAP3K16; MARKK; Serine/threonine-protein kinase TAO1; Kinase from chicken homolog B; MARK Kinase; Prostate-derived sterile 20-like kinase 2; Thousand and one amino acid protein kinase 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1361 MAP3K16 MARKK |
|---|---|
| Alternative Names | TAOK1 KIAA1361 MAP3K16 MARKK Serine/threonine-protein kinase TAO1 Kinase from chicken homolog B MARK Kinase Prostate-derived sterile 20-like kinase 2 Thousand and one amino acid protein kinase 1 |
| Molecular Weight(MW) | 116070 Da |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade |
| Tissue Specificity | Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 57551 |
|---|
Application
Western blot analysis of anti-TAOK1 Pab (AP7085c) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab (1:60 dilution).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
