Application
TBCD Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TBCD antibody detected the TBCD protein (arrow).| Product Name | TBCD Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TBCD; KIAA0988; SSD1; TFCD; Tubulin-specific chaperone D; Beta-tubulin cofactor D; SSD-1; Tubulin-folding cofactor D |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0988 SSD1 TFCD |
|---|---|
| Alternative Names | TBCD KIAA0988 SSD1 TFCD Tubulin-specific chaperone D Beta-tubulin cofactor D SSD-1 Tubulin-folding cofactor D |
| Molecular Weight(MW) | 132600 Da |
| Function | Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Cell junction, tight junction (By similarity). Lateral cell membrane (By similarity). Cytoplasm (By similarity). Cell junction, adherens junction (By similarity) Note=Localized in cell-cell contacts (By similarity) |
| Entrez Gene | 6904 |
|---|---|
| Nucleotide Accession | NP_005984.3 |
Application
TBCD Antibody (N-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TBCD antibody detected the TBCD protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
