Application
Western blot analysis of TBCD7 Antibody (Center) in mouse liver tissue lysates (35ug/lane). TBCD7 (arrow) was detected using the purified Pab.| Product Name | TBCD7 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TBC1D7; TBC1 domain family member 7; Cell migration-inducing protein 23 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TBC1D7 TBC1 domain family member 7 Cell migration-inducing protein 23 |
|---|---|
| Molecular Weight(MW) | 33972 Da |
| Function | Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question |
| Tissue Specificity | Highly expressed in heart, and slightly in kidney, liver and placenta |
| Cellular Localization | Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1- TSC2 complex |
| Entrez Gene | 51256 |
|---|
Application
Western blot analysis of TBCD7 Antibody (Center) in mouse liver tissue lysates (35ug/lane). TBCD7 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
