Application
TDRD1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TDRD1 antibody detected the TDRD1 protein (arrow).| Product Name | TDRD1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TDRD1 Tudor domain-containing protein 1 Cancer/testis antigen 41.1 |
|---|---|
| Molecular Weight(MW) | 132024 Da |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity) |
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers |
| Cellular Localization | Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). Also present in chromatoid body (By similarity) |
| Entrez Gene | 56165 |
|---|---|
| Nucleotide Accession | NP_942090.1 |
Application
TDRD1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TDRD1 antibody detected the TDRD1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
