DNTT TDT DNA nucleotidylexotransferase Terminal addition enzyme Terminal deoxynucleotidyltransferase
Molecular Weight(MW)
58536 Da
Function
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells
Tissue Specificity
A synthetic peptide corresponding to residues in human TDT was used as an immunogen.