Application
TEAD2 Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).Application
TEAD2 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).| Product Name | TEAD2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TEF4 |
|---|---|
| Alternative Names | TEAD2 TEF4 Transcriptional enhancer factor TEF-4 TEA domain family member 2 |
| Molecular Weight(MW) | 49243 Da |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif |
| Tissue Specificity | This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human TEAD2. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 8463 |
|---|---|
| Nucleotide Accession | NP_003589.1 |
Application
TEAD2 Antibody (Center) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).
Application
TEAD2 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
