Application
Western blot analysis of TELO2 Antibody (C-term) in K562 cell line lysates (35ug/lane). TELO2 (arrow) was detected using the purified Pab.Application
TELO2 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TELO2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
TELO2 Antibody (C-term) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | TELO2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TELO2; KIAA0683; Telomere length regulation protein TEL2 homolog; Protein clk-2 homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0683 |
|---|---|
| Alternative Names | TELO2 KIAA0683 Telomere length regulation protein TEL2 homolog Protein clk-2 homolog |
| Molecular Weight(MW) | 91747 Da |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation |
| Tissue Specificity | This TELO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792~822 amino acids from the C-terminal region of human TELO2. |
| Cellular Localization | Cytoplasm. Membrane. Nucleus. Chromosome, telomere (Probable) |
| Entrez Gene | 9894 |
|---|
Application
Western blot analysis of TELO2 Antibody (C-term) in K562 cell line lysates (35ug/lane). TELO2 (arrow) was detected using the purified Pab.
Application
TELO2 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TELO2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
TELO2 Antibody (C-term) flow cytometric analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
