Application
THRAP3 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the THRAP3 antibody detected the THRAP3 protein (arrow).| Product Name | THRAP3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | TRAP150 |
|---|---|
| Alternative Names | THRAP3 TRAP150 Thyroid hormone receptor-associated protein 3 Thyroid hormone receptor-associated protein complex 150 kDa component |
| Molecular Weight(MW) | 108666 Da |
| Function | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be indepenedent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 9967 |
|---|---|
| Nucleotide Accession | NP_005110.2 |
Application
THRAP3 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the THRAP3 antibody detected the THRAP3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
