Application
TIAM2 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TIAM2 antibody detected the TIAM2 protein (arrow).| Product Name | TIAM2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA2016, STEF |
|---|---|
| Alternative Names | TIAM2 KIAA2016 STEF T-lymphoma invasion and metastasis-inducing protein 2 SIF and TIAM1-like exchange factor |
| Molecular Weight(MW) | 190103 Da |
| Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA |
| Tissue Specificity | Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis |
| Cellular Localization | Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites (By similarity) |
| Entrez Gene | 26230 |
|---|---|
| Nucleotide Accession | NP_001010927.1 NP_036586.2 |
Application
TIAM2 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TIAM2 antibody detected the TIAM2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
