Application
A. Western blot analysis on HeLa cell lysate using anti-TIRAP RabMAb (Cat. #AJ1771a), dilution 1:1000.Application
B. Immunohistochemical staining of paraffin-embedded human liver using anti-TIRAP RabMAb (Cat. #AJ1771a).| Product Name | TIRAP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1231Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MAL |
|---|---|
| Alternative Names | TIRAP MAL Toll/interleukin-1 receptor domain-containing adapter protein MyD88 adapter-like protein Adaptor protein Wyatt |
| Molecular Weight(MW) | 23883 Da |
| Function | Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6 |
| Tissue Specificity | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain |
| Cellular Localization | Cytoplasm (By similarity). |
| Entrez Gene | 114609 |
|---|
Application
A. Western blot analysis on HeLa cell lysate using anti-TIRAP RabMAb (Cat. #AJ1771a), dilution 1:1000.
Application
B. Immunohistochemical staining of paraffin-embedded human liver using anti-TIRAP RabMAb (Cat. #AJ1771a).| Application Notes | WB:1:1000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
