Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains
Tissue Specificity
A synthetic peptide corresponding to residues near the C-terminus of human CD8 alpha chain was used as an immunogen.
Cellular Localization
Isoform 1: Cell membrane; Single-pass type I membrane protein