Application
Western blot analysis of TLE1 Antibody (Center) in Jurkat cell line lysates (35ug/lane). TLE1 (arrow) was detected using the purified Pab.| Product Name | TLE1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TLE1 Transducin-like enhancer protein 1 E(Sp1) homolog Enhancer of split groucho-like protein 1 |
|---|---|
| Molecular Weight(MW) | 83201 Da |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG |
| Tissue Specificity | In all tissues examined, mostly in brain, liver and muscle |
| Cellular Localization | Nucleus. Note=Nuclear and chromatin- associated, depending on isoforms and phosphorylation status Hyperphosphorylation decreases the affinity for nuclear components |
| Entrez Gene | 7088 |
|---|
Application
Western blot analysis of TLE1 Antibody (Center) in Jurkat cell line lysates (35ug/lane). TLE1 (arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
