Application
Western blot analysis of anti-TLK2 Antibody (Center) in mouse testis tissue lysates (35ug/lane).TLK2(arrow) was detected using the purified Pab.Application
TLK2 Antibody (K155) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the TLK2 antibody detected the TLK2 protein (arrow).| Product Name | TLK2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TLK2 Serine/threonine-protein kinase tousled-like 2 PKU-alpha Tousled-like kinase 2 |
|---|---|
| Molecular Weight(MW) | 87661 Da |
| Function | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy |
| Tissue Specificity | Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes |
| Cellular Localization | Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2 |
Application
Western blot analysis of anti-TLK2 Antibody (Center) in mouse testis tissue lysates (35ug/lane).TLK2(arrow) was detected using the purified Pab.
Application
TLK2 Antibody (K155) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the TLK2 antibody detected the TLK2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
